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Acronym: MAR
Number / Date of the contract: 51 / 01.08.2006
modul 1
Project Manager: Virginia Borza
Partners: National Inst. of C&D in the Field of Pathology and Medical Science” Victor Babes” (INCDVB), National Inst. of C&D for Material Physics (INCDFM), National Inst. of C&D for chemistry and petrochemistry (ICECHIM), and Institute of Oncology, Bucharest (I
Starting date / finishing date: 2006-08-01 / 2008-09-15
Project value: 1497365 RON
Abstract: Cancer remain one of the leading causes of the death in the most part of the world, although progress was made in early prognosis , in better understanding of the tumor pathophysiology and in opening many new vistas as therapy options. The main reason for failure of the treatment is the poor accesibility of antineoplastic agents to the tumor , requiring higher doses that cause severe toxicity.
Therefore , the development of targeted drug delivery system providing therapeutically effective drug concentration at the tumor site , without having any significant toxic effect on normal cells is a real challenge in cancer therapy. One of such drug delivery system very studied in the last few years is microsferes prepared from different materials and loaded with drugs, antibodies, radioisotopes etc., that have large medical application by pasive or active targeting of the tumor.The obtaining of such particulate delivery system is an important area of nanomedicine.
Hepatocelular carcinoma (HCC) is one of the most common tumor in the world and its incidence is increasing in Europe. Despite the advances in radiotherapy , chemotherapy and immunotherapy, the surgical resection of localized tumor is the only means of improvig the survival of these patients but only in a small percent.Therefore,there is a great need for the development of an effective therapy.
Currently studies demonstrated that microsferes labeled with radioisotopes with high linear energy transfer (LET) such as high energy ? emitters administrated in hepatic artery is a promising alternative for liver cancer therapy , since both primary and metastatic tumors are well vascularized and received the bulk of their blood from this artery.
Because in Romania the incidence of liver cancer is also increased, the aim of this project is to study the preparation of human albumin micro and nanospheres , labeling of these with a high energy ? emitter (188Re) and the evaluation of their therapeutic potential by injection in hepatic artery of an animal with induced tumor. We choose albumin because it is a natural polimer and, the radioisotope 188Re for labeling of these,due to its nuclear properties, suitable for therapy.

1. Studies for obtaining and characterization of HSA micro- and nanospheres (2006-12-15)
2. Studies for obtaining of human albumin microspheres labeled with 188Re and of an animal tumor model (2007-07-15)
3. 1.Studies for obtaining of human albumin nanospheres labeled with 188Re. Results dissemination (2007-12-15)
4. Realization, experimentation and evaluation of the utility of HSA micro- and nanospheres labeled with 188Re by animal studies. . Results dissemination (2008-09-15)

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