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Project List » Smart technology based on novel nanoparticles for improvement of photon and hadrontherapy

Smart technology based on novel nanoparticles for improvement of photon and hadrontherapy
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Acronym: DONANORAD
Contracting Authority: Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI)
Number / Date of the contract: 543PED / 2020-11-23
Programul 2
Project Manager: Iulia Diana Savu
Partners: Politehnica University of Bucharest
Starting date / finishing date: 2020-11-23 / 2022-11-23
Project value: 600000 RON
Abstract: Radiotherapy is essential in the management of cancer treatment. The main limitation of this treatment is the lack of tumor selectivity, which causes severe side effects, and radioresistance. The combined application of nanoparticles and radiotherapy is an emerging therapy concept that may provide local radiosensitization of a tumor and thus increase the therapeutic width. DONANORAD aims to develop a new efficient in vitro technology based on our novel synthesized iron oxide nanoparticles conjugated with polyethylene glycol that encapsulate the chemotherapeutic substance doxorubicin for enhancing the antitumoral effects of the photon and hadrontherapy. To achieve this goal we aim to test the radiosensitizing efficacy of the novel nanoparticles in relevant radioresistant 2D and 3D human cervical carcinoma and chondrosarcoma cell models exposed to photons and hadrons (X-rays, protons of different energies, carbon ions). The strong preliminary results (TRL2) demonstrated the potential of this nano-system to amplify the effect of ionizing radiation and to be a promising candidate in improving photon therapy of cervical adenocarcinoma cells. In addition, both cell models for in vitro testing are developed and biological responses induced by both photons and hadrons are characterized for chondrosarcoma cells. The comparative analysis between different radiation sources, beam types and cell lines will allow us to define an optimized in vitro preclinical model (TRL 3) that could be validated in the next future projects by expanding the research to in vivo experiments.

Objectives: The main objective of the project is to develop a new efficient in vitro technology for increasing antitumor effects using photon or hadrontherapy combined with novel synthesized core-shell iron oxide nanoparticles conjugated with polyethylene glycol that encapsulate the chemotherapeutic substance doxorubicin

THE STAGES OF THE PROJECT AND DELIVERY DATES
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