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Project List » Absolute standardization and study of the decay data of the positron emitters used for pet systems. Assurance of the metrological traceability

Absolute standardization and study of the decay data of the positron emitters used for pet systems. Assurance of the metrological traceability
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Acronym: Idei_0070
Contracting Authority: Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI)
Number / Date of the contract: PNII - 23 / 2011-10-05
Idei - PNII-ID-PCE-2011-3-0070
Project Manager: Maria Sahagia
Partners: -
Starting date / finishing date: 2011-10-05 / 2014-10-04
Project value: 1500000 RON
Abstract: The project proposes the development of a primary activity standard system for PET radionuclides produced and/or used in Romania and study of their decay scheme parameters. The radionuclides proposed to be studied are: 68Ga, 18F, 67Cu and 124I. For each radionuclide, the following actions are envisaged: (i) Obtaining of radionuclides in the IFIN-HH, CRR or U120 cyclotrone, or from import;(ii) Radionuclide purity characterisation;(iii) Development of the methods for absolute standardization with a good precision, of the order of 1 - 2% and comparison of several methods, usually coincidence and liquid scintillation methods;(iv) Precise determination of the decay scheme parameters: half life and emission intensity of gamma-rays, based on the absolutely standardized radioactive solutions and gamma-ray spectrometry;(v) Metrological traceability chain establishment by: calibration of the IFIN-HH secondary standards - ionization chamber CENTRONIC IG12/20A and Gamma-ray spectrometer, and calibration of the measurement equipment used in CRR-IFIN-HH and in PET/CT nuclear medicine units;(vi) Participation at studies on the biodistribution for new PET- RPMs; (vii) Preparation for future CIPM-MRA, BIPM key- or supplementary key- comparisons, after its end; (viii) Publication of results

Objectives: Synthesis

THE STAGES OF THE PROJECT AND DELIVERY DATES
1. Study of literature data for the radionuclide Ga-68 and obtaining of the radionuclide Ga-68 (2011-12-15)
2. Obtaining of the PET standards of Ga-68 and F-18 (2012-12-15)
3. Obtaining of the Cu-67 standards (2013-12-15)
4. Obtaining of the PET standards of I-124 (2014-10-15)

RESULTS
PUBLISHED ARTICLES
RESEARCH TEAM


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